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On Saturday afternoon, March 25, 1911, a pile of garment scraps caught on fire on the eighth floor of the Asch building. On the nineth floor, workers were surrounded by the flames. Some workers tried to escape, but the unlocked stairway was soon blocked by flames and the elevator stopped functioning. The fire escape collapsed under the weight of fleeing workers leaving the remaining workers were left withno escape. On thetenth flo0r,workers escaped to the roofwhere they were able to climb across to roof of another building. Some workers chose to jump rather than burn alive. Of the 250 workers on the ninth floor, 146 died.

Kidney Int 47:845 1995 PubMed ISI ChemPort Aiello FB, Longo DL, Overton R, Takacs L, Durum SK: A role for cytokines in antigen presentation: IL1 and IL4 induce accessory functions of antigenpresenting cells. J Immunol 144:2572 1990Colemann D, Ruef C: IL6: An autocrine regulator of mesangial cell growth. Kidney Int 41:604 1992Smyth MJ, Ortaldo JR, Bere W, Yagita H, Okumura K, Young HA: IL2 and IL6 synergize to augment the poreforming protein gene expression and cytotoxic potential of human peripheral blood T cells. J Immunol 145:1159 1990Horii Y, Muraguchi A, Iwano M, Matsuda T, Hirayama T, Yamada H, Fusii T, Dohi K, Ishikawa H, Ohmoto Y, Yoshizaki K, Hirano T, Kishimoto T: Involvement of IL6 in mesangial proliferative glomerulonephritis. J Immunol 143:3949 1989 PubMed ISI ChemPort Sanceau J, Wijdenes J, Revel M, Wietzerbin J: IL6 and IL6 recptor modulation by IFN and tumor necrosis factor in human monocytic cell line (THP1). J Immunol 147:2630 1991 PubMed ISI ChemPort Oppenheim JJ, Zachariae COC, Mulaida N, Matsushima K: Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu Rev Immunol 9:617 1991 Article PubMed ISI ChemPort Miller MD, Krangel Gafas Oakley MS: Biology and biochemistry of the chemokines: A family of chemotactic and inflammatory cytokines. CRC Crit Rev Immunol 12:17 1992Clore GM, Gronenborn Oakley Radar AM: Threedimensional structures of and chemokines. FASEB J 9:57 1995 PubMed ISI ChemPort Rovin BH, Yoshimura T, Tan L: Cytokineinduced production of monocyte chemoattractant protein1 by cultured human mesangial cells.

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McIlroy as a northern Irishman would have the choice of playing for either Britain or Ireland and he would cause offence no matter which way he went. The Dane, toms shoes who not long ago was world number one and the face of the WTA Tour, has not exactly disappeared off the map since but her name is rarely mentioned these days when the likely grand slam title contenders are being discussed. In fact, in the past year her relationship with Northern Irish golfer Rory McIlroy has become of more interest than her tennis. General Holding Corp (Senaat), which has nearly $7 billionin assets, has approached banks with a proposal for a potentialshare listing. Oilrich Abu Dhabi, the capital of United Arab Emirates, andits neighbouring city state Dubai are leading a revival ofeconomic growth in the United Arab Emirates. Close friend and fellow Northern Irishman Graeme McDowell suggested at last week World Match Play Championship in Bulgaria that McIlroy had split with Horizon. PGA Championship winner told reporters on the eve of the PGA Championship at Wentworth. "Obviously you guys know that something Oakley Sale up.

Top of pageAbstractReferences Desmoids are poorlyunderstood, Boston Bruins locally aggressive, nonmetastasizing fibromatoses that occur with disproportionate frequency in patients with familial adenomatous polyposis (FAP). Their nature is controversial with arguments for and against a neoplastic origin. Neoplastic proliferations are by definition monoclonal, whereas reactive processes originate from a polyclonal background. We examined clonality of 25 samples of desmoid tissue from 11 female FAP patients by assessing patterns of Xchromosome inactivation to calculate a clonality ratio. Polymerase chain reaction (PCR) amplification of a polymorphic CAG short tandem repeat (STR) sequence adjacent to a methylationsensitive restriction enzyme site within the human androgen receptor (HUMARA) gene using fluorescentlabelled primers enabled analysis of PCR products by Applied Biosystems Genescan IITMsoftware. Twentyone samples from nine patients were informative for the assay. Samples from all informative cases comprised a median of 66% (range 0 clonal cells but from the six patients with a clonality ratio 0.5 comprised a median of 71% (65 clonal cells. FAPassociated desmoid tumours are true neoplasms. This may have implications in the development of improved treatment protocols for patients with these aggressive tumours. 2000 Cancer Research CampaignTop of pageReferencesReferences

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